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New, real-time COVID-19 diagnostic tests in development by IU and IU Health research collaboration

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Indiana University researchers from the School of Informatics and Computing at IUPUI and the School of Medicine, in collaboration with Indiana University Health, are developing new diagnostic tests that combine speed and sensitivity for rapid detection of the viral strain.
These tests can eventually be employed for faster diagnosis of health care workers and others who are on the front lines and exposed to COVID-19 patients.

Benchtop and palm-held sequencing-based approaches being developed by IU principal investigator Sarath Janga and colleagues provide solutions for real-time detection of viral infections in clinical samples and further means to control the outbreaks.

“The issue with current accepted approaches for COVID-19 tests is that, while effective at detection, they are slow, with results taking up to a day or longer. We are testing our benchtop sequencing approach, which can potentially be done in two to three hours or even less,” Janga said.

An additional advantage of this novel approach is that testing may be performed at point-of-care in the clinic, rather than transferring samples to the lab, further reducing time and the risk of more infections.

Given these challenges, the team hopes to leverage the findings from these new rapid tests to generate quantitative or semi-quantitative data that can be used to identify the COVID-19 strains prevalent in Indiana and reconstruct the development and evolution of the virus to inform surveillance, public health strategy and potential vaccine design going forward.

Janga’s lab is also supporting current ongoing COVID-19 testing by providing personnel and necessary reagents to the clinical pathology lab at IU Health.

“Viral outbreaks such as COVID-19 need real-time detection of the status of infection in patients to control the spread,” Janga said. “Since there are currently no specific treatments for coronavirus infections, and strains of these RNA viruses evolve rapidly, it is crucial to develop novel techniques that can provide rapid diagnostics and therapeutic intervention.”

Like coronavirus, several viral strains are pathogenic in nature, difficult to detect and easy to transmit, leading to the emergence of pandemics. In the case of an outbreak, it is important to have a method to detect the virus as quickly and accurately as possible in order to prevent its transmission and efficiently treat infected patients.

Currently, most clinical diagnostic tests for viruses depend on either detecting viral antigens or on PCR amplification of viral nucleic acids. These two approaches offer trade-offs and benefits. Antigen tests are typically rapid but have low sensitivity, while PCR is more time-consuming and more sensitive.

Janga and his team are employing a commercially available Oxford Nanopore Technologies sequencing platform that generates full-length DNA or direct RNA virus sequences from clinical samples.

Janga, an associate professor in bioinformatics and data science in the School of Informatics and Computing at IUPUI, and visiting research associate Quoseena Mir, from the Department of Biohealth Informatics in the School of Informatics and Computing, are collaborating with Ryan Relich, head of the IU Health Clinical Pathology Laboratory and assistant professor of clinical pathology and laboratory medicine at IU School of Medicine, and Dr. Raj Vuppalanchi, director of the clinical hepatology division in the IU School of Medicine’s Department of Medicine.

Resident at Mitchell Manor Tests Positive For Covid-19

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A patient from Mitchell Manor has tested positive for COVID-19 while at a local hospital, with two former patients also having tested positive.

HIPAA privacy guidelines prevent the sharing of personal patient information.

Officials shared the following information:

  • On Friday, March 27, a patient was transferred to IU Bedford Hospital with symptoms of respiratory distress. This patient was tested at the hospital and received a positive COVID-19 diagnosis. This patient is still hospitalized.
  • Officials immediately isolated any patient who had known contact with the patient.
  • Officials also recently received notification that two discharged patients who were patients at the facility have tested positive for COVID-19. Both of these patients were already discharged to different care settings prior to testing or diagnosis.

Kathi Hignite-Owens, Executive Director of Mitchell Manor, released this statement this afternoon.

“Prior to this incident and continuing now, we have been following all CMS, CDC and state and local health department guidelines concerning COVID-19. Our associates are being diligent on practicing proper hand hygiene and the use of personal protective equipment, which is recurring education they normally receive, beginning with their orientation at our facility. Every associate is also screened when they arrive for work and when they leave, including checking temperature, to ensure no additional sickness is brought into our building. If they have a fever over 100.4, we send them home and ask them to contact their personal physician.

These guidelines also place restrictions on the entrance of visitors, family members, and vendors. We posted signage on our doors with information on COVID-19. We placed an infection prevention station at the entrance with personal protection supplies.

We continue to work in partnership with the Indiana State Department of Health and the local health department and follow the guidance they provide.”

DOR Waiving Certain Motor Carrier Requirements Due to COVID-19

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Effective today, and in support of Governor Eric Holcomb’s Executive Order 20-02 declaring a public health disaster emergency in Indiana due to COVID-19, Indiana Department of Revenue (DOR) Commissioner Bob Grennes has waived several Motor Carrier Services (MCS) requirements until May 22, 2020.

The waivers affect:

  • Out-of-state motor carriers who are delivering COVID-19 supplies do not need to obtain trip permits or register with the International Registration Plan (IRP) or the International Fuel Tax Agreement (IFTA) before entering Indiana. Upon request, drivers must be able to prove they are hauling food, goods, medical supplies, other equipment and supplies to address the public health threat posed by COVID-19. This waiver will expire on May 22, 2020.
  • IRP or Base Plate registrations (BPR) expiring on March 31, 2020, or April 30, 2020, will not expire until May 31, 2020. Also, an Indiana-based IRP or BPR registrant may delay a registration renewal and/or payment for registrations effective May 1, 2020, until May 31, 2020.
  • Any delayed IRP renewal registrations and/or payments must have an effective renewed IRP registration submitted to DOR by June 1, 2020.
  • Indiana-based IFTA licensees that file quarterly motor carrier fuel tax returns may delay the first quarter’s return (ordinarily due April 30, 2020) to May 31, 2020. Also, following IFTA’s recommendation, DOR waives the requirements to display or possess IFTA credentials until May 22, 2020.

Full details are available here or on DOR’s Motor Carrier Services webpage,

Although DOR in-person customer service is currently suspended due to the COVID-19 health emergency, our MCS customer service team continues to provide support by phone and email, Monday through Friday, 8 a.m. – 4:30 p.m., EST.

To find contact information for specific MCS sections, refer to the contact information listed online.

Davisson: Help available to Hoosier workers, employers impacted by COVID-19

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State Rep. Steve Davisson (R-Salem) encourages Hoosier workers and small businesses impacted by the coronavirus pandemic to access recently expanded state and federal resources for help.

Under Indiana’s temporary “stay-at-home” order, many businesses deemed not essential have laid off staff or cannot pay employees while they are shut down.

To help, Gov. Eric Holcomb expanded unemployment coverage to those impacted, including Hoosiers whose work hours were reduced, those under medical quarantine and employees who cannot continue to work because of lack of child care options.

“During this unprecedented time, Indiana along with the federal government are streamlining and expanding assistance to help Hoosiers impacted by the coronavirus,” Davisson said. “Whether you’re a restaurant worker who suddenly lost their job or a small-business owner who had to close your doors, resources are available to help.”

The Indiana Department of Workforce Development said Hoosiers should file for unemployment insurance if their employment has been interrupted or ended due to COVID-19, and their claim will be evaluated. Individuals must apply for UI benefits online, using a computer or smart phone at Unemployment.IN.gov. For questions, the state asks Hoosiers to review the Frequently Asked Questions, the Claimant Handbook or the online video tutorials before calling the 1-800-891-6499 helpline, which continues to experience a high volume of calls.   

Indiana waived the one-week waiting period for payment of unemployment benefits, and it is retroactive to March 8, 2020. Qualified claimants can typically receive benefits for up to 26 weeks, but this has been extended by an additional 13 weeks. Davisson said thanks to the action of the federal government, unemployed workers who file and are approved will see an extra $600 per week for four months.

Davisson said small businesses, small agricultural cooperatives and nonprofits can receive up to $2 million in low-interest loans through the U.S. Small Business Administration‘s Economic Injury Disaster Loan Program to help meet financial obligations and operating expenses, which could have been met had the disaster not occurred. The loans may be used to pay fixed debts, payroll, accounts payable and other bills that cannot be paid because of the disaster’s impact. The loan interest rates for small businesses and nonprofits are 3.75% and 2.75%, respectively, with terms up to 30 years.

“Many of our small businesses changed their business models to try to make the best adjustments to remain open,” Davisson said. “To help these business owners and those who have shut down completely, these loans can help keep them from closing permanently so they can eventually return to normal operations.”

Davisson said businesses’ merit rate/tax rate will not be impacted if they lay off employees due to the coronavirus.

Gov. Holcomb Extends Restaurant, Bar Restrictions in COVID-19 Fight

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Governor Eric J. Holcomb today signed two executive orders to aid in the fight against COVID-19.

Executive order 20-14 extends the requirements for bars, nightclubs, and restaurants to stay closed to dine-in patrons until April 6 at 11:59 p.m. They may continue to provide take-out and delivery services.

The Governor expects bars, nightclubs, and restaurants to comply with the directive for the safety of Hoosiers in their communities without the need to call for enforcement measures.

However, the state and local boards of health and the Indiana Alcohol and Tobacco Commission (ATC) have been directed by the Governor to take all available administrative and enforcement actions against establishments that continue to offer in-house dining services, in violation of the governor’s order.

Executive order 20-15 eases government operations including permitting electronic notary services to remotely review and approve documents.

On Tuesday, state health officials say an additional 14 people died in Indiana from coronavirus-related illnesses. This brings the state’s total to 49.

Of the new COVID-19 deaths, five involved Indianapolis residents and four were from Lake County. Elkhart, Decatur, Hancock, Ripley and Warren Counties also reported a death.

Confirmed COVID-19 cases grew by 347 to 2,159. The virus has now been reported in 81 of Indiana’s 92 counties. Marion County continues to have the most new reported cases. The county now has 964 cases.

Additional steps taken by the state today include:

  • The Indiana Department of Transportation (INDOT) will hold a virtual job fair for more than 1,000 construction and related positions at 10 a.m. ET on Thursday, April 16.

o   To register for the INDOT Virtual Job Fair, go to https://attendee.gotowebinar.com/register/7684424500148015117.

o   All registrants will receive a link to the recording of the virtual job fair whether they are able to participate live or not.

  • The Indiana Commission for Higher Education will offer free virtual FAFSA filing help for students and families from 1 p.m. to 3 p.m. on Saturday, April 4.

o   Help will be available through the Commission’s Learn More Indiana social media platforms: Facebook (facebook.com/LearnMoreIN), Instagram (@LearnMoreIndiana) and Twitter (@LearnMoreIN)

To see copies of the executive orders, click here: https://www.in.gov/gov/2384.htm

Pavement Rehab Scheduled for U.S. 50 In Shoals, Bedford

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The Indiana Department of Transportation announces lane closures for pavement operations on U.S. 50 between Shoals and Bedford.

Beginning on or around Friday, April 10, contractors will close a lane of U.S. 50 from U.S. 150 in Shoals to State Road 37 in Bedford for a pavement patch and rehabilitation project. During this operation, workers will patch areas of pavement and then mill and resurface the road.

Lane closures are expected to be in place for about 10 hours per day. During that time, traffic will be restricted to one 12-foot lane controlled by flagging operations. Loads wider than 12-feet should seek an alternate route using the nearest state-maintained routes.

Work is expected to last until the beginning of July depending upon weather conditions. INDOT urges drivers to slow down and stay alert near crews.

Bridge painting begins Monday on S.R. 258 west of Seymour in Jackson County

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INDOT contractor Three Star Painting Inc. is scheduled to begin work on a $1.7 million bridge painting contract in Jackson, Jennings and Jefferson Counties next week.

Crews will begin work on the S.R. 258 bridge over the East Fork White River, west of Seymour, on or after Monday, April 6. Significant traffic impacts are not expected, but flagging may be necessary at times.

Other structures include S.R. 3 over the Muscatatuck River in Jennings County, S.R. 7 over Middle Fork Creek and S.R. 56 over Indian-Kentuck Creek in Jefferson County.

The contract was awarded in November 2019 and is expected to be complete by October 31, 2020. Motorists should slow down, use extra caution and drive distraction-free through all work zones. All work is weather dependent.

SR 258 Bridge Painting

Brenna Wise Earns Spot on Senior Class Award First Team

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Indiana senior forward Brenna Wise was selected to the Senior CLASS Award First Team.

The award, chosen by a nationwide vote of Division I women’s basketball coaches, national basketball media and fans, is given annually to the most outstanding senior student-athlete in Division I women’s basketball. Oregon’s Sabrina Ionescu won the overall Senior CLASS Award.

An acronym for Celebrating Loyalty and Achievement for Staying in School®, the Senior CLASS Award focuses on the total student-athlete and encourages students to use their platform in athletics to make a positive impact as leaders in their communities. To be eligible for the award, a student-athlete must be classified as an NCAA Division I senior and have notable achievements in four areas of excellence: classroom, community, character, and competition.

The Pittsburgh, Pa. native is a two-year team captain and started every game for Indiana in her career. In her final season in Cream and Crimson, Wise averaged 7.9 points and a team-high 5.9 rebounds per game. In her career, Wise scored 1,421 career points and 849 rebounds and was a 2018-19 All-Big Ten second-team selection. A double major in marketing and professional sales in IU’s Kelley School of Business, Wise excels in the classroom with a 3.89 GPA and has been named an Academic All-Big Ten selection and a 2019 CoSIDA Academic All-District. She will graduate in May 2020.
 
She is an executive member of the IU Student Athletic Advisory Committee (SAAC). She has volunteered her time with countless organizations including Hoosiers Helping Hoosiers, Emerging Leaders, Hoosier HEROES, Hoosier Readers, IU Best Buddies, Camp Riley, Hoosier Outrun Cancer, Candy Stripe Crew event for disabled and handicapped adult and children, Slam Dunk for Literacy, Habitat for Humanity.

2019-20 Senior CLASS Award First-Team All-Americans

Lauren Cox, Baylor University

Ellie Harmeyer, Belmont University

Sabrina Ionescu, University of Oregon* (winner)

Mikayla Pivec, Oregon State University 

Brenna Wise, Indiana University

2019-20 Senior CLASS Award Second-Team All-Americans

Chelsea Brackmann, Bradley University

Kaila Charles, University of Maryland

Bailey Greenberg, Drexel University

Ruthy Hebard, University of Oregon

Stella Johnson, Rider University

Peyton Williams, Kansas State University

Gov. Holcomb Details COVID-19 Surge Plan

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Governor Eric J. Holcomb Monday signed an executive order and detailed Indiana’s plan for the anticipated spike in COVID-19 cases.

To see a copy of the executive order, click here: https://www.in.gov/gov/2384.htm

“We see a surge coming and we’re calling in the reinforcements, bolstering Indiana’s capacity to provide additional health care services during this emergency,” said Gov. Eric J. Holcomb. “By eliminating licensing barriers and tapping into the available talent pool of healthcare workers, Hoosiers are staffing up and stepping up to meet this challenge head-on.”

The executive order allows the following professionals who do not currently hold an active license to practice:

  • medical professionals who retired or became inactive in the last five years
  • medical professionals who hold licenses in other states
  • medical professionals who held licenses in other states and retired or became inactive in the last five years
  • certain medical students and graduates

These professionals must register with the Indiana Professional Licensing Agency via their website at www.in.gov/pla. These professionals will be able to assist in screenings, telemedicine and other basic procedures to allow regularly licensed medical professionals to be on the frontline.

In Indiana, the baseline number of critical care hospital beds is 1,432. As of Monday, hospitals have already taken steps to increase the number of critical care hospital beds to 1,940. Overall, the state’s plan is to double the number, if needed, by taking existing noncritical care hospital beds, recovery rooms, operating rooms and outpatient facilities, turning them into critical care hospital beds.

In Indiana, the baseline number of ventilators is 1,177 ventilators. As of Monday, hospitals have identified another 750 ventilators that can be used for critical care patients. Overall, the state’s plan is to double the number, if needed, by repurposing ventilators from operating rooms, ambulatory care centers, EMS and the Indiana National Guard.

Additionally, the surge plan calls for moving less critical patients to alternate facilities including neighborhood hospitals, medical clinics and state-owned hospitals, such as unopened floors at the NeuroDiagnostic Institute hospital in Indianapolis and the Richmond State Hospital.

If needed, after all of these steps are exhausted, Indiana will be prepared to put patients in alternative facilities. The Indiana National Guard and Department of Homeland Security, in conjunction with FEMA, are in charge of these plans.

The state of Indiana has been working on plans related to COVID-19 since January, and each hospital has a disaster plan in place. Planning has become more specific for state health and hospital officials as models of the projected impact of coronavirus became available. Based on those models, Indiana’s patient surge is expected to begin soon and the peak is expected to be mid-April to mid-May.

Ball State costume shop joins effort to make medical masks

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As director of Ball State University’s costume shop, Emily Ruiz is used to last second alterations. So, when the COVID-19 pandemic hit Indiana, she quickly led her team in making medical masks for area nursing homes.

In the last few days, the costume shop in the Department of Theatre and Dance has created several hundred masks from cotton fabric. The team is addressing the needs of the medical community in east-central Indiana. Although the items are not the N95 masks recommended for protection against COVID-19, they offer wearers some protection from infections.

“We went from doing last-second alterations on costumes to knocking these out as fast as we could,” said Ruiz, who has been with the University for the past six years. “Our goal was 500, and we hit are close. Then, our job will be to make as many as we can for as long as we are needed.”

She has stated Project Benny: Masks for Muncie, a group of local stitchers that include Ball State retirees, current employees, students, and members of the community. The effort is part of a national movement of theatrical organizations helping meet a critical need.

 “We have already gone through the costume shop’s materials and are seeking more to keep our group working around the clock,” she said. “The requests keep rolling in. I suspect that we will play a role in helping the medical community for some time.”

Department Chair Bill Jenkins calls the efforts heroic as members of the costume shop, Ball State students, and others rise to the challenge.

“This is a perfect example of the Spirit of Beneficence here at Ball State,” he said. “Emily and her collaborators are showing how our University is about more than educating a student. We serve our neighbors.”

But for Ruiz and other members of Theatre and Dance, their work is much like the moments leading up to the start of a major production – full of high energy. They are taking the energy reserved for those crazy moments before the show starts and pouring it into their work.

“We are used to the hems and trims, coming together at the last second to solve costume problems so that the show goes on,” Ruiz said. “I am glad that we can make a difference.”